LYMPHOID NEOPLASIA Tcl1 interacts with Atm and enhances NF- B activation in hematologic malignancies
نویسندگان
چکیده
1Department of Molecular Immunology, Virology and Medical Genetics, The Ohio State University, Columbus, OH; 2Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy; 3Division of Experimental Oncology 2 Centro di Riferimento Oncologico, Aviano, Italy; 4Department of Medicine, University of California at San Diego, La Jolla, CA; and 5Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research, Hebrew University, Jerusalem, Israel
منابع مشابه
Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies.
The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. TCL1 dysregulation in B cells is responsible for the development of an aggressive form of chronic lymphocytic leukemia (CLL), the most common human leukemia. We have investigated the mechanisms underlying the...
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تاریخ انتشار 2011